Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension
Identifieur interne : 000312 ( Main/Exploration ); précédent : 000311; suivant : 000313Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension
Auteurs : Guido Iaccarino [Italie] ; Claudio Borghi [Italie] ; Arrigo F. G. Cicero [Italie] ; Claudio Ferri [Italie] ; Pietro Minuz [Italie] ; Maria Lorenza Muiesan [Italie] ; Paolo Mulatero [Italie] ; Giuseppe Mulè [Italie] ; Giacomo Pucci [Italie] ; Massimo Salvetti [Italie] ; Carmine Savoia [Italie] ; Leonardo Alberto Sechi [Italie] ; Massimo Volpe [Italie] ; Guido Grassi [Italie]Source :
- High Blood Pressure & Cardiovascular Prevention [ 1120-9879 ] ; 2020.
Abstract
Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin–Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.
Url:
DOI: 10.1007/s40292-020-00380-3
PubMed: 31925708
PubMed Central: 7138256
Affiliations:
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xml:lang="fr">Italie</country><wicri:regionArea>Rome</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="GRID">grid.419543.e</institution-id><institution-id institution-id-type="ISNI">0000 0004 1760 3561</institution-id><institution>IRCCS Neuromed,</institution></institution-wrap>Pozzilli, IS Italy</nlm:aff><wicri:noCountry code="subfield">IS Italy</wicri:noCountry></affiliation></author><author><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="GRID">grid.7563.7</institution-id><institution-id institution-id-type="ISNI">0000 0001 2174 1754</institution-id><institution>Department of Medicine and Surgery,</institution><institution>University of Milano-Bicocca,</institution></institution-wrap>Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author></analytic><series><title level="j">High Blood Pressure & Cardiovascular Prevention</title><idno type="ISSN">1120-9879</idno><idno type="eISSN">1179-1985</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin–Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Hedley, Aj" uniqKey="Hedley A">AJ Hedley</name></author><author><name sortKey="Ho, Lm" uniqKey="Ho L">LM Ho</name></author><author><name sortKey="Chau, P" uniqKey="Chau P">P Chau</name></author><author><name sortKey="Wong, Io" uniqKey="Wong I">IO Wong</name></author><author><name sortKey="Thach, Tq" uniqKey="Thach T">TQ Thach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zisman, Ls" uniqKey="Zisman L">LS Zisman</name></author><author><name sortKey="Meixell, Ge" uniqKey="Meixell G">GE Meixell</name></author><author><name sortKey="Bristow, Mr" uniqKey="Bristow M">MR Bristow</name></author><author><name sortKey="Canver, Cc" uniqKey="Canver C">CC Canver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrario, Cm" uniqKey="Ferrario C">CM Ferrario</name></author><author><name sortKey="Jessup, J" uniqKey="Jessup J">J Jessup</name></author><author><name sortKey="Chappell, Mc" uniqKey="Chappell M">MC Chappell</name></author><author><name sortKey="Averill, Db" uniqKey="Averill D">DB Averill</name></author><author><name sortKey="Brosnihan, Kb" uniqKey="Brosnihan K">KB Brosnihan</name></author><author><name sortKey="Tallant, Ea" uniqKey="Tallant E">EA Tallant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name></author><author><name sortKey="Qu, J" uniqKey="Qu J">J Qu</name></author><author><name sortKey="Gong, F" uniqKey="Gong F">F Gong</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onder, G" uniqKey="Onder G">G Onder</name></author><author><name sortKey="Rezza, G" uniqKey="Rezza G">G Rezza</name></author><author><name sortKey="Brusaferro, S" uniqKey="Brusaferro S">S Brusaferro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clerkin, Kj" uniqKey="Clerkin K">KJ Clerkin</name></author><author><name sortKey="Fried, Ja" uniqKey="Fried J">JA Fried</name></author><author><name sortKey="Raikhelkar, J" uniqKey="Raikhelkar J">J Raikhelkar</name></author><author><name sortKey="Sayer, G" uniqKey="Sayer G">G Sayer</name></author><author><name sortKey="Griffin, Jm" uniqKey="Griffin J">JM Griffin</name></author><author><name sortKey="Masoumi, A" uniqKey="Masoumi A">A Masoumi</name></author><author><name sortKey="Disease, Coronavirus" uniqKey="Disease C">Coronavirus Disease</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danser, Ahj" uniqKey="Danser A">AHJ Danser</name></author><author><name sortKey="Epstein, M" uniqKey="Epstein M">M Epstein</name></author><author><name sortKey="Batlle, D" uniqKey="Batlle D">D Batlle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanff, Tc" uniqKey="Hanff T">TC Hanff</name></author><author><name sortKey="Harhay, Mo" uniqKey="Harhay M">MO Harhay</name></author><author><name sortKey="Brown, Ts" uniqKey="Brown T">TS Brown</name></author><author><name sortKey="Cohen, Jb" uniqKey="Cohen J">JB Cohen</name></author><author><name sortKey="Mohareb, Am" uniqKey="Mohareb A">AM Mohareb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glowacka, I" uniqKey="Glowacka I">I Glowacka</name></author><author><name sortKey="Bertram, S" uniqKey="Bertram S">S Bertram</name></author><author><name sortKey="Herzog, P" uniqKey="Herzog P">P Herzog</name></author><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S Pfefferle</name></author><author><name sortKey="Steffen, I" uniqKey="Steffen I">I Steffen</name></author><author><name sortKey="Muench, Mo" uniqKey="Muench M">MO Muench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name></author><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author><author><name sortKey="Huan, Y" uniqKey="Huan Y">Y Huan</name></author><author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name></author><author><name sortKey="Guan, B" uniqKey="Guan B">B Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurwitz, D" uniqKey="Gurwitz D">D Gurwitz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Iaccarino, Guido" sort="Iaccarino, Guido" uniqKey="Iaccarino G" first="Guido" last="Iaccarino">Guido Iaccarino</name></noRegion><name sortKey="Borghi, Claudio" sort="Borghi, Claudio" uniqKey="Borghi C" first="Claudio" last="Borghi">Claudio Borghi</name><name sortKey="Cicero, Arrigo F G" sort="Cicero, Arrigo F G" uniqKey="Cicero A" first="Arrigo F. G." last="Cicero">Arrigo F. G. Cicero</name><name sortKey="Ferri, Claudio" sort="Ferri, Claudio" uniqKey="Ferri C" first="Claudio" last="Ferri">Claudio Ferri</name><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name><name sortKey="Minuz, Pietro" sort="Minuz, Pietro" uniqKey="Minuz P" first="Pietro" last="Minuz">Pietro Minuz</name><name sortKey="Muiesan, Maria Lorenza" sort="Muiesan, Maria Lorenza" uniqKey="Muiesan M" first="Maria Lorenza" last="Muiesan">Maria Lorenza Muiesan</name><name sortKey="Mulatero, Paolo" sort="Mulatero, Paolo" uniqKey="Mulatero P" first="Paolo" last="Mulatero">Paolo Mulatero</name><name sortKey="Mule, Giuseppe" sort="Mule, Giuseppe" uniqKey="Mule G" first="Giuseppe" last="Mulè">Giuseppe Mulè</name><name sortKey="Pucci, Giacomo" sort="Pucci, Giacomo" uniqKey="Pucci G" first="Giacomo" last="Pucci">Giacomo Pucci</name><name sortKey="Salvetti, Massimo" sort="Salvetti, Massimo" uniqKey="Salvetti M" first="Massimo" last="Salvetti">Massimo Salvetti</name><name sortKey="Savoia, Carmine" sort="Savoia, Carmine" uniqKey="Savoia C" first="Carmine" last="Savoia">Carmine Savoia</name><name sortKey="Sechi, Leonardo Alberto" sort="Sechi, Leonardo Alberto" uniqKey="Sechi L" first="Leonardo Alberto" last="Sechi">Leonardo Alberto Sechi</name><name sortKey="Volpe, Massimo" sort="Volpe, Massimo" uniqKey="Volpe M" first="Massimo" last="Volpe">Massimo Volpe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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